Hexa-D-arginine TFA
CAS No. 958204-56-3
Hexa-D-arginine TFA ( Furin Inhibitor II TFA )
Catalog No. M29859 CAS No. 958204-56-3
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameHexa-D-arginine TFA
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NoteResearch use only, not for human use.
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Brief DescriptionHexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
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DescriptionHexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively). (In Vitro):Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.(In Vivo):Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.
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SynonymsFurin Inhibitor II TFA
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorKi: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)
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Research Area——
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Indication——
Chemical Information
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CAS Number958204-56-3
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Formula Weight1068.2
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Molecular FormulaC38H76F3N25O8
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.
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